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Figure 1. Promoter methylation of <t>Dab2</t> in lung cancers and normal lung tissues. (A) The methylation rate of Dab2 in lung cancers was significantly higher than that in corresponding normal lung tissues. T, lung tumor tissues; N, normal lung tissues; M, methylated; U, unmethylated. (B) The methylation status of Dab2 in A549, LTE, H1299, H157, H460, LK2, SPC and BE1 lung cancer cells. (C) Treatment with 5-Aza-dC eliminated the methylation status of Dab2 in A549, LTE and H1299 cells.
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Figure 1. Promoter methylation of Dab2 in lung cancers and normal lung tissues. (A) The methylation rate of Dab2 in lung cancers was significantly higher than that in corresponding normal lung tissues. T, lung tumor tissues; N, normal lung tissues; M, methylated; U, unmethylated. (B) The methylation status of Dab2 in A549, LTE, H1299, H157, H460, LK2, SPC and BE1 lung cancer cells. (C) Treatment with 5-Aza-dC eliminated the methylation status of Dab2 in A549, LTE and H1299 cells.

Journal: International journal of oncology

Article Title: Aberrant hypermethylation and reduced expression of disabled-2 promote the development of lung cancers.

doi: 10.3892/ijo.2013.2084

Figure Lengend Snippet: Figure 1. Promoter methylation of Dab2 in lung cancers and normal lung tissues. (A) The methylation rate of Dab2 in lung cancers was significantly higher than that in corresponding normal lung tissues. T, lung tumor tissues; N, normal lung tissues; M, methylated; U, unmethylated. (B) The methylation status of Dab2 in A549, LTE, H1299, H157, H460, LK2, SPC and BE1 lung cancer cells. (C) Treatment with 5-Aza-dC eliminated the methylation status of Dab2 in A549, LTE and H1299 cells.

Article Snippet: Dab2 siRNA, control siRNA and siRNA reagent system were purchased from Santa Cruz Biotechnology Inc.

Techniques: Methylation

Figure 2. Nuclear and cytoplasmic expression of Dab2 in lung cancers and corresponding normal lung tissues. (A) The expression of p67-Dab2 was reduced in both the cytoplasm and the nucleus of lung cancer tissues compared to that in corresponding normal lung tissues. P96-Dab2 was expressed only in the nucleus of normal lung tissues, but lost in lung cancer tissues. β-actin and histone 3.1 served as internal controls in the cytoplasm and nucleus, respectively. T1, T2 and T3: lung tumor tissues; N1, N2 and N3: corresponding normal lung tissues. (B) The relative expression quantity of Dab2 in lung cancers (cytoplasmic expression, 0.151±0.109; nuclear expression, 0.337±0.181) was significantly less than that in corresponding normal lung tissues (cytoplasmic expression, 0.696±0.337; nuclear expression, 0.901±0.384) (P<0.001). (C) The relative expression quantity of Dab2 in lung cancers with Dab2 promoter methylation (cytoplasmic expression, 0.136±0.103; nuclear expression, 0.301±0.158) was much less than that in corresponding normal lung tissues (cytoplasmic expression, 0.261±0.095; nuclear expression, 0.603±0.101) (P<0.001).

Journal: International journal of oncology

Article Title: Aberrant hypermethylation and reduced expression of disabled-2 promote the development of lung cancers.

doi: 10.3892/ijo.2013.2084

Figure Lengend Snippet: Figure 2. Nuclear and cytoplasmic expression of Dab2 in lung cancers and corresponding normal lung tissues. (A) The expression of p67-Dab2 was reduced in both the cytoplasm and the nucleus of lung cancer tissues compared to that in corresponding normal lung tissues. P96-Dab2 was expressed only in the nucleus of normal lung tissues, but lost in lung cancer tissues. β-actin and histone 3.1 served as internal controls in the cytoplasm and nucleus, respectively. T1, T2 and T3: lung tumor tissues; N1, N2 and N3: corresponding normal lung tissues. (B) The relative expression quantity of Dab2 in lung cancers (cytoplasmic expression, 0.151±0.109; nuclear expression, 0.337±0.181) was significantly less than that in corresponding normal lung tissues (cytoplasmic expression, 0.696±0.337; nuclear expression, 0.901±0.384) (P<0.001). (C) The relative expression quantity of Dab2 in lung cancers with Dab2 promoter methylation (cytoplasmic expression, 0.136±0.103; nuclear expression, 0.301±0.158) was much less than that in corresponding normal lung tissues (cytoplasmic expression, 0.261±0.095; nuclear expression, 0.603±0.101) (P<0.001).

Article Snippet: Dab2 siRNA, control siRNA and siRNA reagent system were purchased from Santa Cruz Biotechnology Inc.

Techniques: Expressing, Methylation

Figure 3. The expression of Dab2 and β-catenin and the proliferative and invasive ability of lung cancer cells after treatment with 5-Aza-dC. (A) Compared with untreated control cells (5-Aza-dC-), the nuclear and cytoplasmic expression of Dab2 was increased, and the nuclear and cytoplasmic expression of β-catenin was reduced in the A549, LTE and H1299 cells after 5-Aza-dC treatment. Histone 3.1 and β-actin served as internal controls in the nucleus and cytoplasm, respec tively. (B) Representative microscope fields of filters under the Matrigel are shown from 5-Aza-dC-treated A549 cells and untreated control cells (5-Aza‑dC-), respectively (original magnification, x400). (C) The number of invasive cells in 5-Aza-dC treated A549 cells was reduced relative to that of untreated control cells (5-Aza-dC-) (bar, SD; *P<0.05). (D) The growth curves indicated that the growth rate of 5-Aza-dC-treated A549 cells was reduced relative to that of untreated A549 cells (5-Aza-dC-) (bar, SD; *P<0.05).

Journal: International journal of oncology

Article Title: Aberrant hypermethylation and reduced expression of disabled-2 promote the development of lung cancers.

doi: 10.3892/ijo.2013.2084

Figure Lengend Snippet: Figure 3. The expression of Dab2 and β-catenin and the proliferative and invasive ability of lung cancer cells after treatment with 5-Aza-dC. (A) Compared with untreated control cells (5-Aza-dC-), the nuclear and cytoplasmic expression of Dab2 was increased, and the nuclear and cytoplasmic expression of β-catenin was reduced in the A549, LTE and H1299 cells after 5-Aza-dC treatment. Histone 3.1 and β-actin served as internal controls in the nucleus and cytoplasm, respec tively. (B) Representative microscope fields of filters under the Matrigel are shown from 5-Aza-dC-treated A549 cells and untreated control cells (5-Aza‑dC-), respectively (original magnification, x400). (C) The number of invasive cells in 5-Aza-dC treated A549 cells was reduced relative to that of untreated control cells (5-Aza-dC-) (bar, SD; *P<0.05). (D) The growth curves indicated that the growth rate of 5-Aza-dC-treated A549 cells was reduced relative to that of untreated A549 cells (5-Aza-dC-) (bar, SD; *P<0.05).

Article Snippet: Dab2 siRNA, control siRNA and siRNA reagent system were purchased from Santa Cruz Biotechnology Inc.

Techniques: Expressing, Control, Microscopy

Figure 4. Nuclear and cytoplasmic expression of Dab2 and β-catenin in A549, H1299 and LTE cells with Dab2 transfection or Dab2 siRNA interference. (A) Both the nuclear and cytoplasmic expression of Dab2 in A549, LTE and H1299 cells with Dab2 gene transfection was significantly enhanced relative to the vector control cells or blank control cells. The expression, both nuclear and cytoplasmic, of β-catenin was markedly reduced. (B) The expression of Dab2 was absent or weak in A549, LTE and H1299 cells with Dab2 siRNA interference relative to the control siRNA or blank cells, whereas, both the nuclear and cytoplasmic expres sion of β-catenin was increased in A549, LTE and H1299 cells. Histone 3.1 and β-actin served as internal controls in the nucleus and in the cytoplasm, respectively.

Journal: International journal of oncology

Article Title: Aberrant hypermethylation and reduced expression of disabled-2 promote the development of lung cancers.

doi: 10.3892/ijo.2013.2084

Figure Lengend Snippet: Figure 4. Nuclear and cytoplasmic expression of Dab2 and β-catenin in A549, H1299 and LTE cells with Dab2 transfection or Dab2 siRNA interference. (A) Both the nuclear and cytoplasmic expression of Dab2 in A549, LTE and H1299 cells with Dab2 gene transfection was significantly enhanced relative to the vector control cells or blank control cells. The expression, both nuclear and cytoplasmic, of β-catenin was markedly reduced. (B) The expression of Dab2 was absent or weak in A549, LTE and H1299 cells with Dab2 siRNA interference relative to the control siRNA or blank cells, whereas, both the nuclear and cytoplasmic expres sion of β-catenin was increased in A549, LTE and H1299 cells. Histone 3.1 and β-actin served as internal controls in the nucleus and in the cytoplasm, respectively.

Article Snippet: Dab2 siRNA, control siRNA and siRNA reagent system were purchased from Santa Cruz Biotechnology Inc.

Techniques: Expressing, Transfection, Plasmid Preparation, Control

Figure 5. Invasiveness and proliferation of A549 cells with Dab2 gene transfection or Dab2 siRNA interference. (A) Representative microscope fields of filters under the Matrigel are shown from Dab2-transfected A549 cells, vector control A549 cells, and blank A549 cells, respectively (original magnification, x400). (B) The number of invasive cells in Dab2-transfected A549 cells was reduced relative to that of vector control A549 and blank A549 cells (bar, SD; *P<0.05). (C) The growth curves indicated that the growth rate of Dab2-transfected A549 cells was reduced relative to that of vector control A549 and blank A549 cells (bar, SD; *P<0.05). (D) The representative microscope fields of filters under the Matrigel are shown from A549 cells with Dab2 siRNA interference, control siRNA A549 cells, and blank A549 cells, respectively (original magnification, x400). (E) The number of invasive cells in A549 cells with Dab2 siRNA interference was increased relative to the control siRNA A549 and blank A549 cells (bar, SD; *P<0.05). (F) The growth curves indicated that the growth rate of A549 cells with Dab2 siRNA interference was increased relative to the control siRNA A549 and blank A549 cells (bar, SD; *P<0.05).

Journal: International journal of oncology

Article Title: Aberrant hypermethylation and reduced expression of disabled-2 promote the development of lung cancers.

doi: 10.3892/ijo.2013.2084

Figure Lengend Snippet: Figure 5. Invasiveness and proliferation of A549 cells with Dab2 gene transfection or Dab2 siRNA interference. (A) Representative microscope fields of filters under the Matrigel are shown from Dab2-transfected A549 cells, vector control A549 cells, and blank A549 cells, respectively (original magnification, x400). (B) The number of invasive cells in Dab2-transfected A549 cells was reduced relative to that of vector control A549 and blank A549 cells (bar, SD; *P<0.05). (C) The growth curves indicated that the growth rate of Dab2-transfected A549 cells was reduced relative to that of vector control A549 and blank A549 cells (bar, SD; *P<0.05). (D) The representative microscope fields of filters under the Matrigel are shown from A549 cells with Dab2 siRNA interference, control siRNA A549 cells, and blank A549 cells, respectively (original magnification, x400). (E) The number of invasive cells in A549 cells with Dab2 siRNA interference was increased relative to the control siRNA A549 and blank A549 cells (bar, SD; *P<0.05). (F) The growth curves indicated that the growth rate of A549 cells with Dab2 siRNA interference was increased relative to the control siRNA A549 and blank A549 cells (bar, SD; *P<0.05).

Article Snippet: Dab2 siRNA, control siRNA and siRNA reagent system were purchased from Santa Cruz Biotechnology Inc.

Techniques: Transfection, Microscopy, Plasmid Preparation, Control